The CCR5Δ32 polymorphism is a 32-base pair deletion in the CCR5 gene that has been associated with slower HIV disease progression. However, its role in immune reconstitution during antiretroviral therapy (ART) remains unclear. We analyzed 236 virologically suppressed people living with HIV (PLHIV) after 24 months of ART, comprising 217 individuals homozygous for the wild-type CCR5 allele and 19 heterozygous carriers of CCR5Δ32...

Increasing life expectancy has been accompanied by a higher prevalence of age-associated conditions, underscoring the need to better understand biological mechanisms of aging and to identify accessible biomarkers. Extracellular vesicles (EVs) are lipid-bilayer vesicles that mediate intercellular communication by transporting proteins, lipids, and regulatory RNAs, including microRNAs (miRNAs). Here, we investigated whether the...

This study evaluated the effects of replacing sugarcane silage with Tithonia diversifolia silage on physiological responses, body temperature, enteric methane (CH 4 ) production, and selected ruminal microbial populations of lambs raised under tropical conditions. Twenty uncastrated crossbred lambs (½ Santa Inês × ½ Dorper), approximately 120 days old and with an initial body weight of 25.74 ± 2.47 kg, were assigned to two die...

Resistance training in rodent models is widely used to investigate muscular and cardiovascular adaptations. Traditional models often attach loads to the tail. The present study aimed to develop and validate a resistance training model for rats using a pulley system combined with a load-bearing vest, allowing progressive overload without tail attachment. Spontaneously hypertensive rats were assigned to control (CTR, n = 4) or r...

Sweet potato is a crop of high nutritional and functional value widely grown in tropical regions. This study aimed to characterize sweet potato farmer-named cultivars grown by local farmers in Bahia, Brazil, based on physicochemical and color traits, and to evaluate the agreement of farmer-based classifications using multivariate approaches. Twenty samples representing different cultivars, collected in the municipalities of Cr...

Aquaculture effluents are increasingly recognized as a strategic resource for agricultural water reuse, especially in semi-arid regions, where water scarcity and fertilizer costs intensify pressure on production systems. Within a circular economy framework, these effluents may simultaneously supply water and nutrients; however, their physicochemical composition must be carefully assessed, since excessive salt loading may impai...

Background Benign prostatic hyperplasia (BPH) is a highly prevalent condition among aging men and a major cause of lower urinary tract symptoms (LUTS). Although α1-adrenoceptor blockers and 5-alpha-reductase inhibitors remain the cornerstone of treatment, their long-term use is frequently limited by adverse effects and suboptimal symptom control. Growing experimental and clinical evidence suggests that chronic prostatic inflam...

Among the many factors that limit sugarcane crop yield, the precise supply of nutrients and water under drip irrigation systems can be the shortcut to higher yields in the field. This research aimed to evaluate the nutritional efficiency of fertigated sugarcane varieties under deficit irrigation strategies. The experiment was conducted in a rain‐out shelter with the soil type Oxisol Typic Ustox. The experimental design adopted...