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The orthohantavirus Puumala virus (PUUV), which is transmitted by bank voles ( Clethrionomys glareolus ), and other vole-borne hantaviruses contain in their small (S) genome segment two overlapping open reading frames, coding for the nucleocapsid protein and the non-structural protein NSs, a putative type I interferon (IFN-I) antagonist. To investigate the role of NSs of PUUV and other orthohantaviruses, the expression pattern...
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