Smoking is a modifiable risk factor for Alzheimer’s disease (AD). The insula plays a vital role in both smoking and cognition. However, the smoking effects on insula-related networks in cognitively normal controls (CN) and mild cognitive impairment (MCI) patients remain unknown. We identified 129 CN (85 non-smokers and 44 smokers) and 83 MCI (54 non-smokers and 29 smokers). Each underwent neuropsychological assessment and MRI...

Initiation of meiosis is the most difficult aspect of inducing competent oocytes differentiation from human stem cells in vitro . Human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs) were cultured with follicle fluid, cytokines and small molecule to induced oocyte-like cells (OLCs) formation through a three-step induction procedure. Expression of surface markers and differentiation potential of germ c...

The dry‐wet climate conditions of an area are mainly determined by the water input (e.g., precipitation, P) and output (e.g., potential evapotranspiration, PET). Based on three dry‐wet indices and the differential equation, this study designed a new attribution method to quantify the contributions of P and PET to the dry‐wet change, so as to determine the dominant factors of the dry‐wet change over whole China (CHINA) and vari...