J. M. Fitzpatrick results 81
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Radon is an established lung carcinogen, but more research is needed to inform whether area-based measures of radon exposure reflect underlying cancer risk. This study, the first of its kind in the UK, aimed to investigate the association between a nationwide indicative radon atlas and lung cancer risk in Northern Ireland, a region in which lung cancer screening programmes are under design. A population-based case–control stud...
Mapping blue carbon ecosystems from Earth observations at a national scale for Papua New GuineaOA Marine
National maps are essential to support the conservation, restoration, and sustainable management of blue carbon ecosystems (BCE). This is particularly important for nations in the Indo-Pacific region, including Papua New Guinea (PNG), that aspire to integrate these ecosystems into their nationally determined contributions (NDCs) for ecosystem accounting. This study focussed on mapping the extent of BCEs in PNG using Earth obse...
Purpose Identifying suspended-sediment (SS) sources, seasonal variability, and phosphorus (P) transported with SS is critical information for basin managers, although there may be concerns about comparability between flow-integrated SS samples used for sediment fingerprinting and discrete samples used for concentrations and loads in basins where SS is mostly silt + clay and(or) one land-use predominates. Objectives were to det...
Motivation Pollinators play a crucial role in maintaining Earth's terrestrial biodiversity. However, rapid human‐induced environmental changes are compromising the long‐term persistence of plant‐pollinator interactions. Unfortunately, we lack robust, generalisable data capturing how plant‐pollinator communities are structured across space and time. Here, we present the EuPPollNet (European Plant‐Pollinator Networks) database,...
Introduction Elasmobranchs, such as sharks and rays, are among the world’s most endangered vertebrates, with over 70% loss in abundance over the past 50 years due to human impacts. Zooarchaeological baselines of elasmobranch diversity, distribution, and exploitation hold great promise for contributing essential historical contexts in the assessment of contemporary patterns in their taxonomic diversity and vulnerability to huma...
A novel in vitro high-content imaging assay for the prediction of drug-induced lung toxicityNARA Subscribed
The development of inhaled drugs for respiratory diseases is frequently impacted by lung pathology in non-clinical safety studies. To enable design of novel candidate drugs with the right safety profile, predictive in vitro lung toxicity assays are required that can be applied during drug discovery for early hazard identification and mitigation. Here, we describe a novel high-content imaging-based screening assay that allows f...
Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibitionNARA Subscribed
The tumour suppressor p16/CDKN2A and the metabolic gene, methyl-thio-adenosine phosphorylase (MTAP), are frequently co-deleted in some of the most aggressive and currently untreatable cancers. Cells with MTAP deletion are vulnerable to inhibition of the metabolic enzyme, methionine-adenosyl transferase 2A (MAT2A), and the protein arginine methyl transferase (PRMT5). This synthetic lethality has paved the way for the rapid deve...
SNAPSHOT USA 2021: A third coordinated national camera trap survey of the U nited S tatesNARA Subscribed
SNAPSHOT USA is a multicontributor, long‐term camera trap survey designed to survey mammals across the United States. Participants are recruited through community networks and directly through a website application ( https://www.snapshot-usa.org/ ). The growing Snapshot dataset is useful, for example, for tracking wildlife population responses to land use, land cover, and climate changes across spatial and temporal scales. Her...
Equivalent roles of marine subsidies and island characteristics in shaping island bird communitiesNARA Subscribed
Aim Species distributions across islands are shaped by dispersal limitations, environmental filters and biotic interactions but the relative influence of each of these processes has rarely been assessed. Here, we examine the relative contributions of island characteristics, marine subsidies, species traits, and species interactions on avian community composition. Location Central Coast region of British Columbia, Canada. Taxon...
Connectivity is critical for stream fish persistence, and fish passage structures are a useful conservation tool to reconnect fragmented systems. The design of fish passage structures is a tradeoff between the area available for construction, slope, and costs associated with the structure. The Longrie–Fecteau fish passage structure was designed to be modular, adjustable to barrier-specific needs, and to have a low slope (2%) t...