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Introduction Small marine carnivores inhabiting fragmented rocky coastlines are increasingly exposed to anthropogenic pressures, yet mortality drivers in these systems remain poorly quantified. Methods We analyzed 22 years of carcass records (2003–2024) and standardized necropsies to evaluate the contribution of anthropogenic causes and their spatial and temporal patterns in marine otters ( Lontra felina ) from north-central C...
Key factors of the deranged antiviral response in elderly patients with COVID-19: a machine-learning analysisNARA Subscribed
Age is a well-known risk factor to develop severe viral respiratory infections, including severe COVID-19. This study aimed to identify the biological alterations linked to severe disease in elderly patients with COVID-19. For this purpose, we employed a derivation cohort with 450 SARS-CoV-2 infected and unvaccinated patients admitted to hospital wards and a validation cohort with 244 SARS-CoV-2 infected and unvaccinated patie...
The physiological and gill health responses of juvenile spotted rose snapper (Lutjanus guttatus) were evaluated at four salinities—8, 16, 24, and 32‰—over a 70-day period. Fish reared at 8‰ exhibited the highest final body weight (126.8 ± 2.6 g), which was significantly higher than their congeners kept at 24‰ (116.0 ± 2.3 g) and 32‰ (116.0 ± 2.3 g). This superior growth at 8‰ coincides with the complete absence of parasitic mo...
Purpose We assessed the effectiveness and safety of cefiderocol in patients with Gram-negative bacterial infections, excluding Acinetobacter spp., in the early access programme (EAP) in Spain. Methods The retrospective, multicentre PERSEUS study (2018–2022) enrolled hospitalised patients with serious Gram-negative infections, except Acinetobacter spp., who received first-time cefiderocol for ≥ 72 h following requests through t...
Purpose This subgroup analysis of the PERSEUS study aimed to describe the effectiveness of cefiderocol treatment in the early access programme in Spain in patients infected by Stenotrophomonas maltophilia , Burkholderia cepacia complex (Bcc) or Achromobacter species. Methods In the retrospective, observational, multicentre PERSEUS study in Spain, the effectiveness and safety of cefiderocol treatment administered for at least 7...
Not only domestic spaces: dismantling short‐term occupations in Level 497D of Cova Gran de Santa Linya (Pre‐Pyrenees, Spain)NARA Subscribed
The Early Upper Paleolithic Level 497D of Cova Gran (Pre‐Pyrenees, Spain) comprises large assemblages of lithics, fauna, hearths, ash accumulations and well‐preserved refitting sequences. This provides exceptional information to analyze spatial patterns and deepen our understanding of the socio‐economic behavior of these human groups. This large interdisciplinary dataset has allowed us to carry out a detailed spatial study bas...
This study aims to evaluate the effect of the transversus abdominis plane (TAP) block on the blood cells and the inflammatory markers neutrophil– to– lymphocyte ratio (NLR), platelet– to– lymphocyte ratio (PLR), and systemic immune– inflammation index (SII) after the laparoscopic ovariectomy (LapOV) in dogs. 72 healthy bitches undergoing LapOV were randomly allocated to the no– TAP group of dogs under inhaled anesthesia (IA),...
The Endangered Limpet Patella ferruginea Integrates a Metapopulation across the Species’ RangeOA Marine
The population genetics of Patella ferruginea Gmelin, 1791, an endangered limpet endemic to the western Mediterranean, has been analysed using 11 polymorphic microsatellite markers on 533 individuals from 18 localities throughout its distribution area. The results showed a deficit of heterozygotes, denoting a certain degree of inbreeding, and, with an overall FST of 0.004, a low level of genetic variability among localities. T...
Age-dependent association of clonal hematopoiesis with COVID-19 mortality in patients over 60 yearsNARA Subscribed
Clonal hematopoiesis, especially that of indeterminate potential (CHIP), has been associated with age-related diseases, such as those contributing to a more severe COVID-19. Four studies have attempted to associate CHIP with COVID-19 severity without conclusive findings. In the present work, we explore the association between CHIP and COVID-19 mortality. Genomic DNA extracted from peripheral blood of COVID-19 patients ( n = 24...