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PROMETHEUS clinical trial protocol: tailoring healthy ageing with lifestyle and nutraceuticalsNARA Subscribed
The d emographic shift toward an older population is accelerating the prevalence of age-related diseases. Precision geromedicine represents a paradigm shift in targeting the biological processes of ageing to optimise health and healthspan, which likely requires multimodal tailored interventions. PROMETHEUS, as part of the XPRIZE healthspan semi-finalist competition, is an 8-week feasibility and exploratory study including 20 m...
Enhanced micropollutant degradation over catalyst-free synergistic activation of periodate and persulfate under solar lightNARA Subscribed
Micropollutants are ubiquitous in water sources, posing threats to both human health and ecosystems. Conventional water and wastewater treatment processes are inefficient in micropollutant removal. In this study, the energy-effective and environmentally friendly solar light–driven periodate (PI) and peroxydisulfate (PDS) synergistic activation process (PI/PDS/solar light) is developed for efficient micropollutant decontaminati...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
Scars are the normal outcome of wound repair and involve a co-ordinated inflammatory and fibrotic process. When a scar does not resolve, uncontrolled chronic inflammation can persist and elicits excessive scarring that leads to a range of abnormal phenotypes such as hypertrophic and keloid scars. These pathologies result in significant impairment of quality of life over a long period of time. Existing treatment options are gen...
Carbohydrate epitopes are immunodominant at the surface of infectious Neoparamoeba spp.NARA Subscribed
Amoebic gill disease, the main disease of concern to the salmon industry in Tasmania, is caused by the amoeba, Neoparamoeba spp. Experimental infection can only be induced by exposure to wild‐type (WT) parasites isolated from the gills of infected fish, as cultured amoebae are non‐infective. To characterize the surface antigens of WT parasites, we produced monoclonal antibodies (mAbs) using subtractive immunization. Mice inocu...
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