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Gut Microbiome‐Metabolome Reconfiguration Associates With Phenotypic Plasticity of Daphnia Under Predation RiskNARA Subscribed
Predation is an important selective pressure shaping phenotypic plasticity in aquatic organisms. As the key mediator between environmental changes and host physiology, gut microbiota and their metabolism play crucial roles in regulating host fitness. Although a few studies have extended the effects of predation risk on gut microbial composition, relatively little is known about whether and how the gut metabolite profiles are r...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Background Workplace heat exposure, intensified by climate change, increasingly threatens workers’ health, safety, and productivity, especially in the agriculture, construction, and manufacturing sectors. However, current evidence is fragmented due to varied study designs, and the absence of an integrated, multidisciplinary synthesis. Objectives This umbrella review synthesizes findings from current systematic reviews and meta...