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Citrus production is a significant agricultural activity in Brazil, the world's largest producer and exporter of orange juice. However, this production faces phytosanitary challenges, including postbloom fruit drop (PFD) caused by fungi of the genus Colletotrichum . The development of this disease is associated with climate conditions, such as temperature and leaf wetness duration (LWD). Citrus production in Brazil has recentl...
Effects of donor and inducer genotype and endosperm texture on haploid induction in maize assessed using R1-NavajoNARA Subscribed
The double haploid (DH) technique in maize ( Zea mays L.) relies on in vivo haploid induction, in which the identification of haploid seeds and seedlings represents a critical step in this technique that determines the efficiency of DH line production. This study aimed to evaluate the effects of endosperm texture, donor genotype, and inducer on putative haploid rates based on the R1-navajo ( R1-nj ) marker and the use of guard...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Peripheral microRNA signature in genetic frontotemporal dementia—findings from the GENFI initiativeNARA Subscribed
Frontotemporal dementia (FTD) is a neurodegenerative disease characterized by significant clinical and genetic heterogeneity, with approximately 40% of cases linked to hereditary genetic mutations, including MAPT , GRN , and C9ORF72 . Recently, microRNAs (miRNAs) have emerged as key regulators of cellular processes related to neurodegeneration and as potential biomarkers for FTD. However, their relevance in presymptomatic stag...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Vitamin B12 (VitB12) plays a crucial role in neural homeostasis, and a high dose is preferred as treatment to support recovery from neural impairments. However, a significant knowledge gap remains regarding its dose-dependent effects, particularly in its influence on cellular recovery following neural damage. To address this, we utilized retinoic acid-differentiated SH-SY5Y cells, as an in vitro neural model, where we induced...
Individual alpha frequency tACS modifies the detection of space–time optical illusionNARA Subscribed
Postdiction is a perceptual phenomenon where the perception of an earlier stimulus is influenced by a later one. This effect is commonly studied using the ‘rabbit illusion’, in which temporally regular, but spatially irregular, stimuli are perceived as equidistant. While previous research has focused on short inter-stimulus intervals (100–200 ms), the role of longer intervals, which may engage late attentional processes, remai...