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Background Although pediatric SARS-CoV-2 infection is usually mild; children with chronic conditions are at increased risk of severe disease. Myeloid Cell Leukemia-1 (MCL-1), a key regulator of mitochondrial apoptosis, is expressed as one anti-apoptotic isoform (MCL-1 L) and two pro-apoptotic isoforms (MCL-1 S and MCL-1ES), but their regulation in pediatric viral infections remains unclear. Methods and results We assessed MCL-...
This study presents the hydrogeological and vegetational context of lowland springs -known in Italian as risorgive or fontanili - in a sector of the southern Po Plain near Turin (north-western Italy). Despite their important ecological role, these springs remain understudied, particularly regarding the effects of climate change and human activities. Not included in Italy’s environmental protection regulations and often poorly...
This paper presents a comprehensive methodology for reconstructing seismic bedrock and investigating its role in areas where seismic (i.e. amplification) and co-seismic (i.e. liquefaction) effects are expected. Reconstructing seismic bedrock can be challenging, particularly in the presence of deep interfaces. To address this, a field campaign was conducted in 2021 in the municipality of Terre del Reno (Po Plain, Italy), an are...
Unsupervised serious video games on the SmartMe&You home telemonitoring platform may enable the assessment of cognitive fluctuations in older individuals, with or without cognitive deficits. Here, we tested their validity in cognitively unimpaired older adults (Healthy) and patients with mild cognitive impairment and mild to moderate dementia due to Parkinson’s disease (PDCD). Such validity was assessed using Mini-Mental State...
Trimethylamine N-oxide (TMAO) disrupts endothelial junction integrity through VE-cadherin Tyr658 phosphorylation in vitroNARA Subscribed
Endothelial dysfunction induced by the accumulation of uremic toxins is a key contributor to cardiovascular disease (CVD) in patients with chronic kidney disease (CKD), as increased endothelial permeability represents an early and critical event in vascular injury and disease progression. This study evaluated the effects of trimethylamine N-oxide (TMAO), a low-molecular-weight uremic toxin, on endothelial junction integrity. E...
Sedentary behavior is a recognized and modifiable risk factor for cognitive decline and dementia across neurodegenerative conditions. This study used a smartwatch-based telemonitoring procedure combined with ecological cognitive assessment to examine whether step counts can capture sedentary behavior and its association with cognitive functioning in patients with mild cognitive impairment (ADMCI) and dementia (ADD) due to Alzh...
The karyotypic landscape of Holocentridae: unveiling patterns of chromosomal evolution in a reef fish familyNARA Subscribed
The squirrelfish family (Holocentridae) represents a ubiquitous and ecologically vital component of coral reef fauna. Their vast oceanic distribution across oceanic barriers in some species presents a unique opportunity to investigate karyotypic evolution on a vast spatial dimension. Here we conducted the first interpopulational cytogenetic analysis of Myripristis jacobus and Holocentrus adscensionis (Atlantic Ocean), and Sarg...