Background The Passiflora genus presents a representative variability of passion fruit species with food, pharmacological and ornamental potential. To understand this genetic variability, it is essential that genetic resources are well characterized for future use in breeding and conservation programs. The aim of this study was to investigate for the first time the diversity genetic and structure population of 88 Passiflora ge...

Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic actions. The toxicity was evaluated on Allium cepa and Artemia salina larvae. Cell viability was also assessed by resazurin in murine cells (Sarcoma 180), human ce...

Tambaqui ( Colossoma macropomum ) is a tropical fish widely cultivated in South America. The increasing demand for this species has heightened interest in its cultivation in subtropical regions with greater thermal variability, where cold shock may induce oxidative stress. This study evaluated the effects of cold shock and subsequent recovery on antioxidant enzyme activity, which included superoxide dismutase (SOD), catalase (...

The conspecific alarm substance (CAS), a chemical compound likely based on glycosaminoglycans, purines, and nitrogen oxide-based pterins, is a natural stressor released by specialized epidermal cells damaged by injury or attack in fish, inducing hormonal and behavioral changes in conspecifics. Its effects in the reproductive context are poorly understood, but previous studies have demonstrated earlier spawning in broodstock ex...

The Copaifera genus (Fabaceae) is widely used in traditional medicine, especially in the form of oleoresin, for the treatment of inflammatory and infectious disorders. However, other plant parts, particularly the leaves, remain comparatively underexplored despite their considerable pharmacological potential. Therefore, this study aimed to systematically review the available literature regarding the chemical composition and ant...

Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...

Spheroids, organoids, and further three-dimensional cellular models represent an intermediate stage of supra-cellular complexity between monolayered cell cultures and animal models. In the present review, we identified conditions in which spheroids and organoids could replace animal models in biomedical research, using long noncoding RNA (lncRNA) research in cancer as a study object. In tumor spheroids and patient-derived orga...

This study aimed to evaluate effects of replacing whole soybean grain with micronized defatted soybean meal (MDSM) in diets of lactating dairy cows on performance, digestion, metabolism, and milk yield and composition. Ten primiparous Jersey cows with an initial body weight (BW) of 410 ± 9 kg and 105 ± 5 days in milk were used. Five replacement levels (0, 25, 50, 75, and 100% of dietary DM) of whole soybean grain with MDSM wer...

This study evaluated the effects of increasing inclusion levels of biological silage produced from tambaqui ( Colossoma macropomum ) by-products (BST) in diets of commercial hens at different ages. A completely randomized design in a 2 × 5 factorial arrangement was adopted, comprising two hen ages (23 and 83 weeks) and five BST inclusion levels (0, 1, 2, 3, and 4%), with four replicates of six birds per treatment. Moderate BST...