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Moraxella tarda sp. nov., a Novel Species Isolated from Nasal Cavity of Cattle with Infectious Bovine KeratoconjunctivitisNARA Subscribed
A novel bacterial species was isolated from the nasal mucosa of Hereford cattle exhibiting early clinical signs of infectious bovine keratoconjunctivitis on a beef cattle farm in the Pampa biome, southern Brazil, in 2018. Cells were Gram-stain-negative cocci and exhibited slow growth under standard laboratory conditions, with optimal growth at 35 °C, pH 7.5, and 1.0% NaCl. The draft genome comprised approximately 1.86 Mbp (Gen...
On-Demand Hospital Manufacturing of Baclofen Lozenges Using Pharmaceutical 3D PrintingNARA Subscribed
Purpose Dysphagia in neurological patients complicates oral drug administration. Manual preparation of lozenges/troches lacks precision and scalability. This study investigates the feasibility of implementing a pharmaceutical 3D printer in a hospital pharmacy for the automated production of personalized baclofen troches. Methods Baclofen troches were manufactured in a hospital pharmacy setting, both manually and via pharmaceut...
Aquaculture intensification has increased the susceptibility of farmed fish to infectious diseases, which are traditionally managed with antibiotics. Growing environmental concerns and the emergence of antimicrobial resistance, however, have driven the search for more sustainable approaches to disease management. White grape marc, a polyphenol-rich by-product of the wine-making industry with known antimicrobial and antioxidant...
Towards the design of a selective trap for an invasive snakeNARA Subscribed
Aim Species richness is generally lower in marine than in terrestrial ecosystems, but the reasons behind this disparity remain unclear. This study examines whether marine mammals diversify at a slower pace than their non‐marine counterparts, aiming to shed light on the factors explaining potential diversification differences among them. Location Global. Time Period Contemporary. Major Taxa Studied Mammals. Methods We combined...
Phenolic compounds and epigenetic mechanisms regulating gene expression: effects on human healthNARA Subscribed
Phenolic compounds are a large class of phytochemicals with relevant physiological effects that are naturally found in plant-origin foods and derived products. Beneficial effects associated with polyphenol consumption are related to their ability to prevent and/or counteract disease features: they exert anti-inflammatory, antioxidant and anticancer effects, as well as protective actions against metabolic diseases. Phenolic com...
Cortical volumetry and longitudinal cognitive changes in Parkinson’s disease: insights from the COPPADIS cohortNARA Subscribed
Cognitive decline is a major non-motor symptom in Parkinson’s disease (PD), often linked to brain atrophy. This study examines the relationship between cortical atrophy and age groups in predicting cognitive decline in PD over five years. 188 PD patients from the COPPADIS cohort were stratified by age: young (30–55 years, N = 47), middle-aged (56–65 years, N = 59), and older adults (66–75 years, N = 82). Baseline cortical volu...