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Introduction Picocyanobacteria from the genera Prochlorococcus and Synechococcus thrive across the globe in aquatic environments, have relatively small genomes, and have growth dynamics regulated by both viral interactions and abiotic conditions, making them excellent model organisms for exploring host-pathogencoevolution. Methods We developed and refined methods to sample and sequence cyanobacteria, cyanophages, and measured...
Multiple Pleistocene refugia for Arctic Bell‐Heather revealed with genomic analyses of modern and historic plantsNARA Subscribed
Aim Arctic plants survived the Pleistocene glaciations in unglaciated refugia. The number, ages, and locations of these refugia are often unclear. We use high‐resolution genomic data from present‐day and Little‐Ice‐Age populations of Arctic Bell‐Heather to re‐evaluate the biogeography of this species and determine whether it had multiple independent refugia or a single refugium in Beringia. Location Circumpolar Arctic and Coas...
This study investigates the anti-inflammatory properties of extracts prepared from the leaves of eight southern African medicinal plants used traditionally to treat inflammation and pain. The inhibitory effect of aqueous and ethanol extracts on the release of pro-inflammatory cytokines was determined in lipopolysaccharide (LPS) stimulated and unstimulated RAW 264.7 murine macrophage cells. The levels of interleukin (IL)-1β, IL...
Wave separation analysis (WSA) reveals the impact of forward- and backward-running waves on the arterial pressure pulse, but the calculations require a flow waveform. This study investigated (1) the variability of the ascending aortic flow waveform in children and adolescents with/without a childhood heart disease history (CHD); (2) the accuracy of WSA obtained with a representative flow waveform (RepFlow), compared with the t...
Evaluation of oxytetracycline leaching from pregelatinized starch‐coated medicated fish feedNARA Subscribed
The rapid growth and intensification of aquaculture industries have led to an increased use of antibiotics. Consequently, growing concerns have mounted over the environmental contamination of these drugs from medicated feeds and the risk that this poses for antimicrobial resistance. To circumvent environmental leaching, farmers topcoat medicated feeds with oil; however, this only partially addresses the issue. This study inves...
Prolonged electronic screen use can cause digital eye strain. It can be difficult to rectify due to increasing smartphone reliance, potentially leading to serious public health problems. To investigate the association between time spent on smartphones and digital eye strain (DES) among Hong Kong Chinese school-aged children. Of a total of 1,508 students (748 males, 49.6%) from 8 to 14 years old (mean age = 10.91 years, SD = 2....
The seas of Southeast Asia are home to some of the world’s most diverse ecosystems and resources that support the livelihoods of millions of people. Climate change will bring temperature changes, acidification and other environmental change, with uncertain consequences for human and natural systems, but there has been little regional-scale climate modelling of the marine ecosystem. We present initial dynamically downscaled pro...
Conservation approaches to social-ecological systems have largely been informed by a framing of preserving nature for its instrumental societal benefits, often ignoring the complex relationship of humans and nature and how climate change might impact these. The Nature Futures Framework (NFF) was developed by the Task Force on scenarios and models of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Se...
Mechanisms of breast cancer metastasisNARA Subscribed
Invasive breast cancer tends to metastasize to lymph nodes and systemic sites. The management of metastasis has evolved by focusing on controlling the growth of the disease in the breast/chest wall, and at metastatic sites, initially by surgery alone, then by a combination of surgery with radiation, and later by adding systemic treatments in the form of chemotherapy, hormone manipulation, targeted therapy, immunotherapy and ot...
Essential outcomes for COP26NARA Subscribed
Gamma4: a genetically versatile Gammaproteobacterial nifH phylotype that is widely distributed in the North Pacific OceanNARA Subscribed
Summary Despite the increasing reports of non‐cyanobacterial diazotrophs (NCDs) in pelagic waters, only one NCD (GammaA) has been relatively well described, whose genome and physiology are still unclear. Here we present a comprehensive analysis of the biogeography and ecophysiology of a widely distributed NCD, Gamma4. Gamma4 was the most abundant Gammaproteobacterial NCD along transects across the subtropical North Pacific. Us...
Meeting Paris agreement objectives will temper seabird winter distribution shifts in the North Atlantic OceanNARA Subscribed
We explored the implications of reaching the Paris Agreement Objective of limiting global warming to Alle alle , Fratercula arctica , Uria aalge , Uria lomvia and Rissa tridactyla ) using tracking data for ~1500 individuals through resource selection functions based on mechanistic modeling of seabird energy requirements, and a dynamic bioclimate envelope model of seabird prey. Future winter distributions were predicted to shif...