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Modeling of gene regulatory networks: an annotated glossaryNARA Subscribed
Environmental Variability Shapes Life‐History Trade‐Offs Within and Between Populations of a Long‐Lived SeabirdNARA Subscribed
Individuals face a trade‐off between allocating resources to reproduction or self‐maintenance, yet the drivers of the existence and strength of such trade‐off have been hard to determine. Environmental conditions are thought to play a crucial role, as long‐lived species are predicted to favour more precautionary life‐history strategies in variable environments. However, empirical evidence remains limited. Using long‐term monit...
Pro-longevity compounds extend Caenorhabditis elegans male lifespan and reproductive healthspanNARA Subscribed
Sex differences in aging are robust and ubiquitous. Demographic differences in aging generated by sex have long been recognized, but the underlying biological basis for these differences and the potential for sex-specific interventions remain understudied. To explore sex differences in the response to pro-longevity interventions, we utilized the C. elegans aging model and asked whether male lifespan and reproductive healthspan...
A core facet of the National Institute on Aging’s mission is to identify pharmacological interventions that can promote human healthy aging and long life. As part of the comprehensive effort toward that goal, the NIA Division of Biology of Aging established the Caenorhabditis Intervention Testing Program (CITP) in 2013. The C. elegans model (with an ~ 21 day lifespan) has led the field in dissection of longevity genetics and o...
The Caenorhabditis Intervention Testing Program (CITP) is an NIH-funded research consortium of investigators who conduct analyses at three independent sites to identify chemical interventions that reproducibly promote health and lifespan in a robust manner. The founding principle of the CITP is that compounds with positive effects across a genetically diverse panel of Caenorhabditis species and strains are likely engaging cons...
Morphological similarities between skates of the genus Dipturus in the north‐eastern Atlantic and Mediterranean have resulted in longstanding confusion, misidentification and misreporting. Current evidence indicates that the common skate is best explained as two species, the flapper skate ( Dipturus intermedius ) and the common blue skate ( D. batis ). However, some management and conservation initiatives developed prior to th...
As alien invasive species are a key driver of biodiversity loss, understanding patterns of rapidly changing global species compositions depends upon knowledge of invasive species population dynamics and trends at large scales. Within this context, the Ponto-Caspian region is among the most notable donor regions for aquatic invasive species in Europe. Using macroinvertebrate time series collected over 52 years (1968–2020) at 26...
Is the future female for turtles? Climate change and wetland configuration predict sex ratios of a freshwater speciesNARA Subscribed
Climate change and land‐use change are leading drivers of biodiversity decline, affecting demographic parameters that are important for population persistence. For example, scientists have speculated for decades that climate change may skew adult sex ratios in taxa that express temperature‐dependent sex determination (TSD), but limited evidence exists that this phenomenon is occurring in natural settings. For species that are...
Globalization has led to the introduction of thousands of alien species worldwide. With growing impacts by invasive species, understanding the invasion process remains critical for predicting adverse effects and informing efficient management. Theoretically, invasion dynamics have been assumed to follow an “invasion curve” (S‐shaped curve of available area invaded over time), but this dynamic has lacked empirical testing using...
Functional traits offer a rich quantitative framework for developing and testing theories in evolutionary biology, ecology and ecosystem science. However, the potential of functional traits to drive theoretical advances and refine models of global change can only be fully realised when species‐level information is complete. Here we present the AVONET dataset containing comprehensive functional trait data for all birds, includi...
Evidence of egg‐laying grounds for critically endangered flapper skate ( Dipturus intermedius ) off Orkney, UKNARA Subscribed
Essential fish habitats (EFHs) are critical for fish life‐history events, including spawning, breeding, feeding or growth. This study provides evidence of EFHs for the critically endangered flapper skate ( Dipturus intermedius ) in the waters around the Orkney Isles, Scotland, based on citizen‐science observation data. The habitats of potential egg‐laying sites were parametrised as >20 m depth, with boulders or exposed bedrock...
Cigarette smoking is the major cause of chronic obstructive pulmonary disease. Considerable attention has been paid to the reduced harm potential of nicotine-containing inhalable products such as electronic cigarettes (e-cigarettes). We investigated the effects of mainstream cigarette smoke (CS) and e-vapor aerosols (containing nicotine and flavor) generated by a capillary aerosol generator on emphysematous changes, lung funct...
COSORE: A community database for continuous soil respiration and other soil‐atmosphere greenhouse gas flux dataNARA Subscribed
Globally, soils store two to three times as much carbon as currently resides in the atmosphere, and it is critical to understand how soil greenhouse gas (GHG) emissions and uptake will respond to ongoing climate change. In particular, the soil‐to‐atmosphere CO 2 flux, commonly though imprecisely termed soil respiration ( R S ), is one of the largest carbon fluxes in the Earth system. An increasing number of high‐frequency R S...
The use of flavoring substances is an important element in the development of reduced-risk products for adult smokers to increase product acceptance and encourage switching from cigarettes. In a first step towards characterizing the sub-chronic inhalation toxicity of neat flavoring substances, a study was conducted using a mixture of the substances in a base solution of e-liquid, where the standard toxicological endpoints of t...
TRY plant trait database – enhanced coverage and open accessNARA Subscribed
Plant traits—the morphological, anatomical, physiological, biochemical and phenological characteristics of plants—determine how plants respond to environmental factors, affect other trophic levels, and influence ecosystem properties and their benefits and detriments to people. Plant trait data thus represent the basis for a vast area of research spanning from evolutionary biology, community and functional ecology, to biodivers...
Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemical interventionsNARA Subscribed
The goal of the Caenorhabditis Intervention Testing Program is to identify robust and reproducible pro-longevity interventions that are efficacious across genetically diverse cohorts in the Caenorhabditis genus. The project design features multiple experimental replicates collected by three different laboratories. Our initial effort employed fully manual survival assays. With an interest in increasing throughput, we explored a...