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Optimisation of Metal Recovery From Metallurgical Residues Through Carbothermal Reduction: Experimental and Thermodynamic investigationNARA Subscribed
The de-fossilisation of industrial processes, particularly in the steel and cement sectors, accelerates structural changes in material flows. In Austria, the transition from blast furnaces to electric arc furnace steel production will significantly affect the availability and composition of industrial by-products, which are currently used to reduce the clinker factor in the cement industry. This study addresses the valorisatio...
The pluralistic natural capital values of a tropical cityNARA Subscribed
Polychlorinated biphenyls (PCBs) are widespread environmental contaminants that interfere with xenobiotic metabolism, primarily by modulating cytochrome P450 (CYP) enzymes. However, their pharmacokinetic consequences in exposed individuals remain poorly defined. Here, we investigated the impact of PCB exposure on CYP enzyme activity using a combined clinical pharmacokinetic and in vitro mechanistic approach. Ten occupationally...
Treatment options for progressive MS (PMS) are limited in numbers and efficacy, which is most pronounced in patients with inflammatory disease activity. Immunoglobulin M (IgM) oligoclonal bands (OCBs) may identify a subset of PMS with more active inflammatory disease. The effects of natalizumab and methylprednisolone on intrathecal inflammation and the association of IgM OCBs with other biomarkers in PMS is uncertain. In the c...
Urban tree cover targets: The good, the bad and the SMARTNARA Subscribed
Global interest in microplastics is increasing, with numerous organisations collecting data on microplastics in the environment. However, disparate sampling, analysis, and reporting methods limit our ability to integrate data, hindering a global understanding of microplastic occurrence, effects and dynamics. Drawing on international directives and collaborations, we present a comprehensive guideline of harmonised and standardi...
Establishment of Coala: a novel 3D and 2D cancer cell line derived from colorectal cancer liver metastasisNARA Subscribed
Metastatic colorectal cancer is one of the most critical causes of cancer-related dead in patients suffering this type of malignancy. As the liver metastases are found in almost 25–50% of all colorectal cancer patients, there is an urgent need for suitable in vitro and in vivo models. To the best of our knowledge, only a limited number of well-described 2D or 3D organoid/spheroid cell lines originated from human liver metastas...
Recent findings suggest that global warming is altering the timing of trees' phenological activities, including earlier emergence from winter dormancy. While early‐season warming can boost carbon uptake, tree growth does not seem to benefit. The underlying mechanisms and the altered intra‐ and inter‐annual growth dynamics, as well as their interaction with environmental factors, remain poorly understood. We analysed daily‐reso...
Motivation Here, we make available a second version of the BioTIME database, which compiles records of abundance estimates for species in sample events of ecological assemblages through time. The updated version expands version 1.0 of the database by doubling the number of studies and includes substantial additional curation to the taxonomic accuracy of the records, as well as the metadata. Moreover, we now provide an R packag...
Metabolic activation of WHO-congeners PCB28, 52, and 101 by human CYP2A6: evidence from in vitro and in vivo experimentsNARA Subscribed
Despite extensive research on the metabolism of polychlorinated biphenyls (PCBs), knowledge gaps persist regarding their isoform-specific biotransformation pathways. This study aimed to elucidate the role of different cytochrome P450 enzymes in PCB metabolism, focusing on WHO-congeners 2,4,4′-trichlorobiphenyl (PCB28), 2,2′,5,5′-tetrachlorobiphenyl (PCB52), and 2,2′,4,5,5′-pentachlorobiphenyl (PCB101). Utilizing engineered HEK...
Annotation of multiple regions of interest across the whole mouse brain is an indispensable process for quantitative evaluation of a multitude of study endpoints in neuroscience digital pathology. Prior experience and domain expert knowledge are the key aspects for image annotation quality and consistency. At present, image annotation is often achieved manually by certified pathologists or trained technicians, limiting the tot...