Purpose Niemann-Pick type C (NPC) disease caused by mutations in cholesterol transporters NPC1 or NPC2 is characterized by cholesterol accumulation in late endosomes/lysosomes (LE/Lys). The activation of alternative cholesterol export routes that can bypass NPC1/2 deficiency could provide therapeutic opportunities. We previously demonstrated that gene depletion of the Rab7-GTPase activating protein (GAP) TBC1D15, which hydroly...

A new basidiomycete, Clavulina mollis , is described based on morphological features and DNA sequence analyses. This fungus, collected in Yunnan Province, China, is characterized by its coralloid basidiomata growing in caespitose clusters, branching two to five times, polychotomous toward the apices and irregularly dichotomous to polychotomous at the base; a monomitic hyphal system with clamped generative hyphae; pale yellow,...