Stephanie Wagner results 33
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Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Predicting the progression of MCI and Alzheimer’s disease on structural brain integrity and other features with machine learningNARA Subscribed
Machine learning (ML) on structural MRI data shows high potential for classifying Alzheimer’s disease (AD) progression, but the specific contribution of brain regions, demographics, and proteinopathy remains unclear. Using Alzheimer’s Disease Neuroimaging Initiative (ADNI) data, we applied an extreme gradient-boosting algorithm and SHAP (SHapley Additive exPlanations) values to classify cognitively normal (CN) older adults, th...
Because continuous and high‐resolution records are scarce in the polar Urals, a multiproxy study was carried out on a 54 m long sediment succession (Co1321) from Lake Bolshoye Shchuchye. The sedimentological, geochemical, pollen and chironomid data suggest that glaciers occupied the lake's catchment during the cold and dry MIS 2 and document a change in ice extent around 23.5–18 cal ka bp. Subsequently, meltwater input, sedime...
Climate and environmental history at Lake Levinson‐Lessing, Taymyr Peninsula, during the last 62 kyrNARA Subscribed
The 45.95 m‐long sediment succession shown in core Co1401 from Lake Levinson‐Lessing allows the reconstruction of the largely unexplored environmental and climatic history of the Taymyr Peninsula of the past 62 kyr. The core was analysed with a multidisciplinary approach including lithological, granulometric, geochemical and pollen analyses. The proxy data indicate a relatively stable, herb‐dominated environment with only subt...
Health-related fitness knowledge in adolescence: evaluation of a new test considering different psychometric approaches (CTT and IRT)NARA Subscribed
Fostering health-related fitness knowledge is a common goal across physical education curricula. However, carefully developed knowledge tests that satisfy the psychometric criteria of educational assessment are lacking. Therefore, two studies were conducted to evaluate a newly developed health-related fitness knowledge test within the framework of classical test and item response theory regarding item quality, test reliability...
Flower preformation is a widespread phenomenon in perennial plants from temperate and cold regions. An advanced preformation status reduces the prefloration period and thus increases the chance to mature seeds in time. Despite the particular importance of this strategy for high-mountain plants, studies are rare. Here we investigated how the length of the growing season impacts floral development, and to what extent floral deve...
Microglia Activation in Retinal Ischemia Triggers Cytokine and Toll-Like Receptor ResponseNARA Subscribed
Mechanisms and progression of ischemic injuries in the retina are still incompletely clarified. Therefore, the time course of microglia activation as well as resulting cytokine expression and downstream signaling were investigated. Ischemia was induced in one eye by transiently elevated intraocular pressure (60 min) followed by reperfusion; the other eye served as a control. Eyes were processed for RT-qPCR and immunohistochemi...
Use of Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Drug-Food Interactions: an Industry PerspectiveNARA Subscribed
The effect of food on pharmacokinetic properties of drugs is a commonly observed occurrence affecting about 40% of orally administered drugs. Within the pharmaceutical industry, significant resources are invested to predict and characterize a clinically relevant food effect. Here, the predictive performance of physiologically based pharmacokinetic (PBPK) food effect models was assessed via de novo mechanistic absorption models...
Local Wnt3a treatment restores bone regeneration in large osseous defects after surgical debridement of osteomyelitisNARA Subscribed
Impaired bone homeostasis caused by osteomyelitis provokes serious variations in the bone remodeling process, thereby involving multiple inflammatory cytokines to activate bone healing. We have previously established a mouse model for post-traumatic osteomyelitis and studied bone regeneration after sufficient debridement. Moreover, we could further characterize the postinfectious inflammatory state of bony defects after debrid...