Key Biodiversity Areas (KBAs) are sites of significance for the global persistence of biodiversity. Based on the Global Standard for the Identification of Key Biodiversity Areas (KBA Standard), published in 2016, sites are currently being assessed for KBA designation in a growing number of countries across the world. For these assessments, the KBA criteria are applied to all species and ecosystems with available data. We revie...

BMN 250 is being developed as enzyme replacement therapy for Sanfilippo type B, a primarily neurological rare disease, in which patients have deficient lysosomal alpha- N -acetylglucosaminidase (NAGLU) enzyme activity. BMN 250 is taken up in target cells by the cation-independent mannose 6-phosphate receptor (CI-MPR, insulin-like growth factor 2 receptor), which then facilitates transit to the lysosome. BMN 250 is dosed direct...

Farming freshwater prawns with fish in rice fields is widespread in the coastal region of southwest B angladesh because of favourable resources and ecological conditions. This article provides an overview of an ecosystem‐based approach to integrated prawn–fish–rice farming in southwest B angladesh. The practice of prawn and fish farming in rice fields is a form of integrated aquaculture–agriculture, which provides a wide range...

Wastewater‐fed aquaculture is generally in decline. The 12 500 ha East Kolkata Wetlands (EKW) Ramsar site in peri‐urban Kolkata, India, is the only large‐scale formal system still operating and appears to demonstrate a high degree of resilience. This paper identifies aspects of wastewater‐fed aquaculture in the EKW that contribute to its sustained operation. The Driving Forces, Pressures, State, Impact, Response (DPSIR) framew...