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CRISPR/Cas9-mediated miR-21 editing in high-grade urothelial carcinoma cells and its biological effectsNARA Subscribed
Background Urothelial carcinoma, the predominant form of bladder cancer, represents a global public health challenge due to its high rates of recurrence and progression. At the molecular level, microRNA-21 (miR-21) has been characterized as an “oncomir” because of its ability to negatively regulate tumor suppressor genes, thereby promoting tumor survival and progression. In this context, the CRISPR/Cas9 system has emerged as a...
Aim We investigate the distribution of dispersal modes — endozoochory (via animal ingestion), synzoochory (via animal seed accumulation) and anemochory (via wind)—and seed mass of woody plants across Brazilian ecosystems, testing whether their relative abundance in local plant communities could be predicted by climate, edaphic factors and dispersal agents (e.g., the main vectors moving seeds). We expected climate to be the mai...
Spread of the polyphagous pest Scirtothrips dorsalis (Thysanoptera: Thripidae) in Brazilian cropsNARA Subscribed
The thrips, Scirtothrips dorsalis Hood (Thysanoptera: Thripidae), is native to Asia. Although it is still listed as a quarantine pest in Brazil, it has also been reported in this country. In the present study, we expanded the distribution of this species to southeastern Brazil and provided new records for the northeastern region, where it was initially detected. In addition, we warn about its expansion in the country, comment...
At the end of April and beginning of May 2024, the state of Rio Grande do Sul, Brazil, experienced an unprecedented climatic disaster. A combination of meteorological factors,including extreme accumulated precipitation,and the region’s topography led to a rapid and severe rise in river levels. Therefore, numerous cities were inundated, leaving both people and animals homeless, and resulting in several fatalities. Given the mag...
Detection of physiological changes in knee cartilage using parametric T2 relaxation maps estimated with a dictionary methodNARA Subscribed
Purpose To investigate half-marathon running and recovery effects on knee articular cartilage (KAC) health in athletes, using dictionary-matching T 2 maps, to detect changes and recovery patterns in KAC. Methods Eleven asymptomatic volunteers (4 females, 7 males; mean age 40 ± 5 years, mean BMI 22.7 ± 1.4 kg/m 2 ) completed a fixed-pace half-marathonwere studied. All were right-knee dominant and engaged in regular running. Sag...
Functional diversity of Brazilian bees: revealing the unique patterns of the NeotropicsNARA Subscribed
Bees are essential for ecosystem functioning, pollinating many wild and crop plant species. Predicting which species are most vulnerable to global changes, and how their loss may impact ecosystems and human well-being, is critical. Comprehensive information on bee response and effect traits is fundamental to these assessments. However, the Raunkiærian shortfall—insufficient trait data—remains significant for bees, particularly...
Background and aims Endocan has been scarcely explored in COVID-19, especially regarding its modulation by veno-venous extracorporeal membrane oxygenation (VV-ECMO), hypertension or previous renin–angiotensin–aldosterone system (RAAS) inhibitors treatment. We compared endocan and other endotheliitis markers in hospitalized COVID-19 patients and assessed their modulation by VV-ECMO, hypertension and previous RAAS inhibitors tre...
Genome‐Wide Population Structure in a Marine Keystone Species, the European Flat Oyster ( Ostrea edulis )NARA Subscribed
Ostrea edulis, the European flat oyster, was once a widespread economically and ecologically important marine species, but has suffered dramatic declines over the past two centuries. Consequently, there has been a surge in European restoration efforts, many of which focus on restocking as a conservation measure. In this study, we used whole‐genome sequencing (WGS) data to investigate the population structure, demographic histo...
Prediction of future railway ballast tamping requirementsNARA Subscribed