C. M. Moore results 306
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The future of how we understand and manage ecosystems largely depends on direct and continuous observations that connect local territories to planetary processes. Latin America (LATAM: Mexico, Central and South America, and the Caribbean) hosts ecosystems critical for regulating global carbon, water, and energy cycles. However, persistent underinvestment in science and technology hampers the long‐term monitoring capacity neede...
Fentanyl decreases arterial blood oxygen saturation more than furanylfentanyl in mice due to increased apneaNARA Subscribed
Rationale Fatal opioid overdoses involving synthetic opioids have increased >10-fold over the past 8 years. Fentanyl, a potent synthetic opioid acting at the mu-opioid receptor (MOR), has largely replaced heroin as the predominant illicit opioid available. Various analogs have been synthesized from the fentanyl scaffold, including 2-furanylfentanyl, one of the most trafficked analogs from 2019 to 2024. Despite its prevalence,...
Global patterns and regional insights into kelp forest protection, restoration, and stewardshipNARA Subscribed
Kelp forests are among the most extensive and productive coastal ecosystems, yet they remain underrepresented in global conservation policy despite widespread declines driven by interacting global- (i.e., ocean warming, marine heatwaves) to local-scale stressors. At the same time, kelp conservation and restoration efforts are expanding rapidly across regions, but measures of success and syntheses tend to primarily focus on eco...
Ecological seasonality describes the dynamic adaptation of species to changes in the biotic community and suggests predators should alter space use synchronously with seasonal prey availability. We assessed seasonal space use states (i.e., periods of similar movement and resource use) of mainland gray wolves ( Canis lupus ), moose ( Alces alces ), and white-tailed deer ( Odocoileus virginianus ) on the Grand Portage Indian Res...
Interpretable deep learning reveals spatiotemporal MRI features of brain aging that align with neurodegenerationNARA Subscribed
Cortical thinning and atrophy are hallmarks of brain aging that have been characterized using magnetic resonance imaging (MRI). Brain aging involves many neuroanatomic features whose effects on brain structure remain unexplored. To address this challenge, we trained interpretable deep neural networks (DNNs) to estimate brain age (BA) from T 1 -weighted ( T 1 w) MRI. By identifying MRI features unapparent to humans, DNNs can fi...
Ti solubility in biotite at low pressure in metapelitic systems: the Torres del Paine caseNARA Subscribed
The Torres del Paine Intrusive Complex (TPIC) is a shallowly emplaced pluton surrounded by a well-defined contact aureole, providing an ideal setting to test Ti-in-biotite thermometry. We compare existing Ti-in-biotite thermometers with phase petrology constraints and found that they systematically overestimate peak metamorphic temperatures. This discrepancy arises from a significant increase in Ti solubility at low pressures...
Success of restoration strategies in preventing extirpation of 2 critically endangered coral speciesNARA Subscribed
An unprecedented marine heatwave in 2023 caused widespread coral bleaching and mortality throughout the Caribbean. In the Florida Keys (USA), 2 foundation species, elkhorn coral ( Acropora palmata ) and staghorn coral ( Acropora cervicornis ), were severely affected. These species have been the primary focus of reef restoration in Florida for decades. Substantial losses of these species occurred in outplanted populations, in o...
Childhood maltreatment is pervasive – with an estimated 1 in 4 children experiencing abuse or neglect at some point in their lifetime. Exposure to childhood maltreatment has been associated with detrimental neurodevelopmental changes to brain structure and function in stress-sensitive regions and regions with extended developmental periods. Such regions include the frontoparietal regions (e.g., middle frontal gyrus and dorsola...
Alzheimer’s disease (AD) disproportionately affects women and carriers of the apolipoprotein E ε4 allele (APOE4), yet little is known about how sex and APOE interact to influence white matter (WM) integrity during disease progression. We integrated diffusion MRI and matched blood transcriptomic data to investigate these interactions and their underlying biological mechanisms. WM microstructure was quantified using diffusion te...
Micro‐Refuges or Ecological Traps: Context‐Dependent Effects of Rock Pools on Intertidal Biodiversity Across LatitudesNARA Subscribed
Aim We investigated how local‐scale environmental heterogeneity influences biodiversity patterns across broad biogeographic gradients, using intertidal microhabitats as a model system within one of the most environmentally stressful ecosystems on Earth. Location Intertidal habitats at 26 locations (two rocky shore sites per location) across six continents, spanning 98° of latitude (38°S to 60°N). Time Period 2019–2022. Major T...
Climate change and local pressures are eroding the health and performance of many watersheds and their freshwater ecosystems, pushing these complex social‐ecological systems to the boundaries of their safe operating space. Here, we offer a synthetic perspective on the downscaled application of the safe operating space concept to inform the stewardship of watersheds in this time of rapid climate change, with particular focus on...