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Implications of Endogenous Small Regulatory RNAs Survey in Mollusks on Gene Silencing ApproachesNARA Subscribed
Mollusks are an abundant group of animals, with many ecologically and economically important members that are phylogenetically distinct from nearly all genetic model organisms. This study provides a clade-wide evaluation of small RNA biogenesis pathways, with emphasis on the eastern oyster, Crassostrea virginica . A more thorough characterization of these molecules supports rationale design of RNA interference (RNAi) approache...
Observing air-sea interactions on a global scale is essential for improving Earth system forecasts. Yet these exchanges are challenging to quantify for a range of reasons, including extreme conditions, vast and remote under-sampled locations, requirements for a multitude of co-located variables, and the high variability of fluxes in space and time. Uncrewed Surface Vehicles (USVs) present a novel solution for measuring these c...
As global surface temperatures have increased with human‐induced climate change, notable compound climate extremes in the New Zealand (NZ) region associated with atmospheric heatwaves (AHWs) and marine heatwaves (MHWs) have occurred in the past 6 years. Natural modes of variability that also played a key role regionally include the Interdecadal Pacific Oscillation (IPO), El Niño/Southern Oscillation (ENSO) and changes in the l...
The ocean is the main heat reservoir in Earth’s climate system, absorbing most of the top-of-the-atmosphere excess radiation. As the climate warms, anomalously warm and fresh ocean waters in the densest layers formed near Antarctica spread northward through the abyssal ocean, while successions of warming and cooling events are seen in the deep-ocean layers formed near Greenland. The abyssal warming and freshening expands the o...
Prolonging survival in good health is a fundamental societal goal. However, the leading determinants of disability-free survival in healthy older people have not been well established. Data from ASPREE, a bi-national placebo-controlled trial of aspirin with 4.7 years median follow-up, was analysed. At enrolment, participants were healthy and without prior cardiovascular events, dementia or persistent physical disability. Disab...
The scale of the Deepwater Horizon disaster was and is unprecedented: geographic extent, pollutant amount, countermeasure scope, and of most relevance to this Research Topic issue, range of ecotypes affected. These ecotypes include coastal/nearshore, continental shelf, deep benthic, and open-ocean domains, the last of which is the subject of this synthesis. The open-ocean ecotype comprises ~90% of the volume of the Gulf of Mex...
Systems analysis of miRNA biomarkers to inform drug safetyNARA Subscribed
microRNAs (miRNAs or miRs) are short non-coding RNA molecules which have been shown to be dysregulated and released into the extracellular milieu as a result of many drug and non-drug-induced pathologies in different organ systems. Consequently, circulating miRs have been proposed as useful biomarkers of many disease states, including drug-induced tissue injury. miRs have shown potential to support or even replace the existing...
The pelagic Gulf of Mexico (GoM) is a complex system of dynamic physical oceanography (western boundary current, mesoscale eddies), high biological diversity, and community integration via diel vertical migration and lateral advection. Humans also heavily utilize this system, including its deep-sea components, for resource extraction, shipping, tourism, and other commercial activity. This utilization has had impacts, some with...
Relationships between abundance of post‐larval and juvenile carangid (jacks) fishes and physical oceanographic conditions were examined in the northern Gulf of Mexico (GoM) in 2011 with high freshwater input from the Mississippi River. Generalized additive models ( GAM s) were used to explore complex relationships between carangid abundance and physical oceanographic data of sea surface temperature ( SST ), sea surface height...
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