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Temperate Forest Floors: Ecosystem Hubs in Transition?NARA Subscribed
The forest floor (FF) plays a key role in carbon, nutrient, and water cycling. It is the biologically most active compartment of forest soils, highly responsive to environmental conditions. Yet, its response to current changes in environmental conditions and forest management is understudied. Temperate forests are among the best studied ecosystems globally, providing the necessary ecological and biogeochemical background infor...
Small Molecules to Elevate Rab7-GTPase Activity and Lower Cholesterol Accumulation in Niemann-Pick Type C DiseaseNARA Subscribed
Purpose Niemann-Pick type C (NPC) disease caused by mutations in cholesterol transporters NPC1 or NPC2 is characterized by cholesterol accumulation in late endosomes/lysosomes (LE/Lys). The activation of alternative cholesterol export routes that can bypass NPC1/2 deficiency could provide therapeutic opportunities. We previously demonstrated that gene depletion of the Rab7-GTPase activating protein (GAP) TBC1D15, which hydroly...
Ten questions concerning indoor dustNARA Subscribed
The Toxicology Investigators Consortium 2024 Annual ReportNARA Subscribed
Cerebellar ataxia, neuropathy, vestibular-areflexia syndrome (CANVAS) has been linked to biallelic intronic repeat-expansions in RFC1 . Video-head-impulse testing (vHIT) offers a quantitative assessment of the angular vestibulo-ocular reflex (aVOR) of all three canals. We evaluated patterns of peripheral-vestibular impairment, its change over time and evaluated correlations with other parameters. PubMed/Embase were searched fo...
Soil gross mineral N production and consumption processes are crucial regulators of plant productivity and N loss from croplands. Substituting synthetic fertilizers by integrating legumes in cultivation systems is common in organic farming, but research on its long-term impact on dynamics of gross soil N transformation and associated environmental N loss is scarce. In particular, studies at a temporal resolution that allows fo...
The Toxicology Investigators Consortium 2023 Annual ReportNARA Subscribed
The field of linguistics concerns itself with understanding the human capacity for language. Compositionality is a key notion in this research tradition. Compositionality refers to the notion that the meaning of a complex linguistic unit is a function of the meanings of its constituent parts. However, the question as to whether compositionality is a defining feature of human language is a matter of debate: usage-based and cons...